New and Highly Sensitive Spectrophotometric Method for the Determination of Paracetamol in Preformulation and Dosage Forms

A simple and highly sensitive spectrophotometric method for the determination of paracetamol has been developed. The employed methodology involves reaction of paracetamol with iron(III) and subsequent reaction with ferricyanide in acid medium, which yield a Prussian blue product with maximum absorption at 730 nm. Beer’s law was obeyed for the paracetamol concentration range from 0.20-3.00 g ml .The relative standard deviation (n = 8) was vary between 0.26 and 2.30 % for 1.0 g ml paracetamol. The commonly encountered excipients and additives that accompany pharmaceutical preparations did not interfere with the determination. The method was applied for the determination of paracetamol in pharmaceutical preparations. This method is cheap, rapid, easy, accurate and precise which can be used for the routine estimation of paracetamol in pharmaceutical preparations. © 2012 Universal Research Publications. All rights reserved